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CAS RN 606143-52-6

CAS RN 606143-52-6

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1

Selumetinib, TRC

CAS: 606143-52-6 Molecular Formula: C17 H15 Br Cl F N4 O3 Molecular Weight (g/mol): 457.68 Synonym: 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-,5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide,6-(4-Bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide,ARRY 142886,AZD 6244,G 00039805,Koselugo,NSC 741O78,Selumetinib IUPAC Name: 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide SMILES: Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO

CAS 606143-52-6
Molecular Weight (g/mol) 457.68
SMILES Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO
Synonym 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-,5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide,6-(4-Bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide,ARRY 142886,AZD 6244,G 00039805,Koselugo,NSC 741O78,Selumetinib
IUPAC Name 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Molecular Formula C17 H15 Br Cl F N4 O3
2

STEMCELL Technologies AZD6244

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

ENCOMPASS_PREFERRED
CAS 606143-52-6
Molecular Formula C17H15BrClFN4O3
3

Selumetinib, MedChemExpress

MedChemExpress Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 457.68
Color White
Physical Form Powder
Chemical Name or Material Selumetinib
Grade Research
SMILES O=C(C1=C(C(F)=C2N=CN(C2=C1)C)NC3=CC=C(C=C3Cl)Br)NOCCO
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.01%
CAS 606143-52-6
Solubility Information DMSO : 10 mg/mL (21.85 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Synonym AZD6244 ARRY-142886
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H15BrClFN4O3
Formula Weight 457.68