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  5. Tocris Bioscience™ ST 034307

Tocris Bioscience™ ST 034307
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Product Code. 30000896
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Product Code. 30000896 Supplier Tocris Bioscience™ Supplier No. 6271/10

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Description

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 133406-29-8
Molecular Formula C10H4Cl4O2

Specifications

Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 20mM in ethanol
Formula Weight 297.95
Physical Form Solid
Purity >98%
Molecular Weight (g/mol) 297.94
Chemical Name or Material 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
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