CAS RN 623142-96-1
CAS RN 623142-96-1
IUPAC Name:
1-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-2-methoxyphenyl}-3-[1-(1,3-thiazol-2-yl)ethyl]urea
Synonyms:
1-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-2-methoxyphenyl}-3-[1-(1,3-thiazol-2-yl)ethyl]urea
Molecular Weight (g/mol):
480.54
Molecular Formula:
C24H24N4O5S
InChi Key:
SHPFDGWALWEPGS-UHFFFAOYNA-N
SMILES:
COC1=C(NC(=O)NC(C)C2=NC=CS2)C=CC(OC2=CC=NC3=CC(OC)=C(OC)C=C23)=C1
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Tocris Bioscience™ Ki 20227
CAS: 623142-96-1 Molecular Formula: C24H24N4O5S
2
Ki20227, MedChemExpress
MedChemExpress Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction.
