CAS RN 1622849-58-4
CAS RN 1622849-58-4
IUPAC Name:
5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl)-1,2-oxazole-3-carboxamide
Synonyms:
5-benzyl-N-(5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl)-1,2-oxazole-3-carboxamide
Molecular Weight (g/mol):
377.4
Molecular Formula:
C21H19N3O4
InChi Key:
KNOUWGGQMADIBV-UHFFFAOYNA-N
SMILES:
CN1C2=CC=CC=C2OCC(NC(=O)C2=NOC(CC3=CC=CC=C3)=C2)C1=O
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GSK481, MedChemExpress
MedChemExpress GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC50 of 1.3 nM, which inhibits Ser166 phosphorylation in wild-type human RIP1 (IC50=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC50 of 10 nM.
