Tetrahydroisoquinolines

Organic heterocyclic compounds that consist of an isoquinoline ring with no double bonds; contains a benzene ring fused to a six-membered ring with one nitrogen atom and five carbon atoms.

16 – 30 of 94 results

(S)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, 98%

CAS: 78879-20-6 Molecular Formula: C15H18NO4 Molecular Weight (g/mol): 276.31 MDL Number: MFCD00143845 InChI Key: HFPVZPNLMJDJFB-LBPRGKRZSA-M Synonym: boc-tic-oh,s-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,s-n-boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,boc-l-tic-oh,s-2-boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,3s-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,n-boc-l-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,3s-2-tert-butoxycarbonyl-3,4-dihydro-1h-isoquinoline-3-carboxylic acid,3s-2-2-methylpropan-2-yl oxycarbonyl-3,4-dihydro-1h-isoquinoline-3-carboxylic acid PubChem CID: 664088 IUPAC Name: (3S)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid SMILES: CC(C)(C)OC(=O)N1CC2=CC=CC=C2C[C@H]1C([O-])=O

Pricing and Availability
Specifications

PubChem CID	664088
CAS	78879-20-6
Molecular Weight (g/mol)	276.31
MDL Number	MFCD00143845
SMILES	CC(C)(C)OC(=O)N1CC2=CC=CC=C2C[C@H]1C([O-])=O
Synonym	boc-tic-oh,s-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,s-n-boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,boc-l-tic-oh,s-2-boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,3s-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,n-boc-l-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,3s-2-tert-butoxycarbonyl-3,4-dihydro-1h-isoquinoline-3-carboxylic acid,3s-2-2-methylpropan-2-yl oxycarbonyl-3,4-dihydro-1h-isoquinoline-3-carboxylic acid
IUPAC Name	(3S)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
InChI Key	HFPVZPNLMJDJFB-LBPRGKRZSA-M
Molecular Formula	C15H18NO4

1,2,3,4-Tetrahydroisoquinoline, 97%

CAS: 91-21-4 Molecular Formula: C9H11N Molecular Weight (g/mol): 133.19 MDL Number: MFCD00006896 InChI Key: UWYZHKAOTLEWKK-UHFFFAOYSA-N Synonym: tetrahydroisoquinoline,1,2,3,4-tetrahydro-isoquinoline,isoquinoline, 1,2,3,4-tetrahydro,1,2,3,4-tetrahydro isoquinoline,1,2,3,4-tetrahydro-2-isoquinoline,1,2,3,4-tetrahydro-2-azanaphthalene,unii-56w89fbx3e,chembl14346,3,4-dihydro-1h-isoquinoline,tetrahydroisoquinolin PubChem CID: 7046 IUPAC Name: 1,2,3,4-tetrahydroisoquinoline SMILES: C1CC2=CC=CC=C2CN1

Pricing and Availability
Specifications

PubChem CID	7046
CAS	91-21-4
Molecular Weight (g/mol)	133.19
MDL Number	MFCD00006896
SMILES	C1CC2=CC=CC=C2CN1
Synonym	tetrahydroisoquinoline,1,2,3,4-tetrahydro-isoquinoline,isoquinoline, 1,2,3,4-tetrahydro,1,2,3,4-tetrahydro isoquinoline,1,2,3,4-tetrahydro-2-isoquinoline,1,2,3,4-tetrahydro-2-azanaphthalene,unii-56w89fbx3e,chembl14346,3,4-dihydro-1h-isoquinoline,tetrahydroisoquinolin
IUPAC Name	1,2,3,4-tetrahydroisoquinoline
InChI Key	UWYZHKAOTLEWKK-UHFFFAOYSA-N
Molecular Formula	C9H11N

(R)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, 98%

CAS: 115962-35-1 Molecular Formula: C15H18NO4 Molecular Weight (g/mol): 276.31 MDL Number: MFCD00143818 InChI Key: HFPVZPNLMJDJFB-GFCCVEGCSA-M Synonym: boc-d-tic-oh,r-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,boc-d-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,n-boc-d-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,3r-2-tert-butoxy carbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,r---n-boc-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid,3r-2-tert-butoxycarbonyl-3,4-dihydro-1h-isoquinoline-3-carboxylic acid,r---2-tertbutoxycarbonyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid,boc-d-tic,ambotzbaa1055 PubChem CID: 688607 IUPAC Name: (3R)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid SMILES: CC(C)(C)OC(=O)N1CC2=CC=CC=C2C[C@@H]1C([O-])=O

Pricing and Availability
Specifications

PubChem CID	688607
CAS	115962-35-1
Molecular Weight (g/mol)	276.31
MDL Number	MFCD00143818
SMILES	CC(C)(C)OC(=O)N1CC2=CC=CC=C2C[C@@H]1C([O-])=O
Synonym	boc-d-tic-oh,r-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,boc-d-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,n-boc-d-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,3r-2-tert-butoxy carbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,r---n-boc-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid,3r-2-tert-butoxycarbonyl-3,4-dihydro-1h-isoquinoline-3-carboxylic acid,r---2-tertbutoxycarbonyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid,boc-d-tic,ambotzbaa1055
IUPAC Name	(3R)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
InChI Key	HFPVZPNLMJDJFB-GFCCVEGCSA-M
Molecular Formula	C15H18NO4

MRT68921 dihydrochloride, MedChemExpress

MedChemExpress MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	507.5
Color	Off-White
Physical Form	Solid
Chemical Name or Material	MRT68921 dihydrochloride
Grade	Research
SMILES	[H]Cl.O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5.[H]Cl
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.22%
CAS	2080306-21-2
Solubility Information	H2O : 31.25 mg/mL (61.58 mM; Need ultrasonic) ∣DMSO : 8.33 mg/mL (16.41 mM; ultrasonic and warming and heat to 60°C)
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₅H₃₆Cl₂N₆O
Formula Weight	507.5

GSK591, MedChemExpress

MedChemExpress GSK591 (EPZ015866) is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	380.48
Color	White
Physical Form	Solid
Chemical Name or Material	GSK591
Grade	Research
SMILES	O=C(C1=CC(NC2CCC2)=NC=C1)NC[C@H](O)CN3CC4=C(C=CC=C4)CC3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.86%
CAS	1616391-87-7
Solubility Information	DMSO : ≥ 135 mg/mL (354.81 mM)
Synonym	EPZ015866 GSK3203591
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₂₈N₄O₂
Formula Weight	380.48

IQ 1, MedChemExpress

MedChemExpress IQ 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	362.42
Color	Orange
Physical Form	Solid
Chemical Name or Material	IQ 1
Grade	Research
SMILES	CC(C1=CC=C(/N=N/C(C(N)=O)=C2NC(C)(C)CC3=CC=CC=C3/2)C=C1)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.69%
CAS	331001-62-8
Solubility Information	DMSO : ≥ 33 mg/mL (91.05 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₂N₄O₂
Formula Weight	362.42

(-)-Isocorypalmine, MedChemExpress

MedChemExpress (-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a dopamine receptor ligand. Recombinant CYP719A21 displays strict substrate specificity and high affinity (Km=4.63 ± 0.71 μM) for (-)-Isocorypalmine.

Pricing and Availability

Diclofensine hydrochloride, MedChemExpress

MedChemExpress Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	358.69
Color	White
Physical Form	Solid
Chemical Name or Material	Diclofensine hydrochloride
Grade	Research
SMILES	CN1CC2=C(C=CC(OC)=C2)C(C3=CC=C(Cl)C(Cl)=C3)C1.[H]Cl
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	99.88%
CAS	34041-84-4
Solubility Information	H2O : ≥ 52 mg/mL (144.97 mM)
Synonym	Ro 8-4650 hydrochloride
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₁₇H₁₈Cl₃NO
Formula Weight	358.69

NBI-98782, MedChemExpress

MedChemExpress NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	319.44
Color	White
Physical Form	Solid
Chemical Name or Material	NBI-98782
Grade	Research
SMILES	COC(C=C1CCN2C[C@@H](CC(C)C)[C@@H]3O)=C(C=C1[C@]2(C3)[H])OC
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.38%
CAS	85081-18-1
Solubility Information	DMSO : 33.33 mg/mL (104.34 mM; Need ultrasonic)
Synonym	(+)-DTBZ (+)-α-Dihydrotetrabenazine (+)-α-DHTBZ
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₂₉NO₃
Formula Weight	319.44

YS-49 monohydrate, MedChemExpress

MedChemExpress YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.

Pricing and Availability
Specifications

Percent Purity	99.56%
Molecular Weight (g/mol)	404.3
Color	Gray
Physical Form	Solid
Chemical Name or Material	YS-49 monohydrate
Grade	Research
SMILES	OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.O.Br
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
For Use With (Application)	Neuroscience-Neuromodulation
Molecular Formula	C₂₀H₂₂BrNO₃
Formula Weight	404.3

N-Nornuciferine, MedChemExpress

MedChemExpress N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	281.35
Color	Off-White
Physical Form	Solid
Chemical Name or Material	N-Nornuciferine
Grade	Research
SMILES	COC1=C(OC)C2=C3C(CCN[C@]3([H])CC4=CC=CC=C24)=C1
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.18%
CAS	4846-19-9
Solubility Information	DMSO : 100 mg/mL (355.43 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₉NO₂
Formula Weight	281.35

JDTic dihydrochloride, MedChemExpress

MedChemExpress JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	538.55
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	JDTic dihydrochloride
Grade	Research
SMILES	O=C([C@@H]1NCC2=C(C=CC(O)=C2)C1)N[C@@H](C(C)C)CN3C[C@H](C)[C@](C)(C4=CC=CC(O)=C4)CC3.[H]Cl.[H]Cl
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	99.44%
CAS	785835-79-2
Solubility Information	DMSO : 100 mg/mL (185.68 mM; Need ultrasonic) ∣H2O : 50 mg/mL (92.84 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₈H₄₁Cl₂N₃O₃
Formula Weight	538.55

Narciclasine, MedChemExpress

MedChemExpress Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	307.26
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	Narciclasine
Grade	Research
SMILES	O=C1N[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)C=C2C3=C1C(O)=C4C(OCO4)=C3
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.06%
CAS	29477-83-6
Solubility Information	DMSO : ≥ 26 mg/mL (84.62 mM)
Health Hazard 1	H302∣H340
Synonym	Lycoricidinol
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₄H₁₃NO₇
Formula Weight	307.26

Encequidar mesylate, MedChemExpress

MedChemExpress Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	784.83
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Encequidar mesylate
Grade	Research
SMILES	O=C(C1=CC(C2=CC=CC=C2O1)=O)NC3=CC(OC)=C(OC)C=C3C4=NN(C5=CC=C(CCN6CC7=C(C=C(OC)C(OC)=C7)CC6)C=C5)N=N4.CS(=O)(O)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.68%
CAS	849675-87-2
Solubility Information	DMSO : 25 mg/mL (31.85 mM; Need ultrasonic)
Synonym	HM30181 mesylateHM30181A mesylate
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₃₉H₄₀N₆O₁₀S
Formula Weight	784.83

NVP-CGM097, MedChemExpress

MedChemExpress NVP-CGM097 is a potent and selective MDM2 inhibitor with IC50 of 1.7±0.1 nM for hMDM2.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	659.26
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	NVP-CGM097
Grade	Research
SMILES	ClC(C=C1)=CC=C1[C@@H](C2=CC(OC(C)C)=C(OC)C=C2C3)N(C4=CC=C(N(C[C@@H]5CC[C@@H](N6CC(N(C)CC6)=O)CC5)C)C=C4)C3=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.06%
CAS	1313363-54-0
Solubility Information	DMSO : ≥ 50 mg/mL (75.84 mM)
Synonym	CGM097
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₈H₄₇ClN₄O₄
Formula Weight	659.26

Tetrahydroisoquinolines

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