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Tocris Bioscience™ ZZL 7
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Product Code. 30000035
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Quantity:
10 mg
Unit Size:
10mg
Product Code. Quantity unitSize
30000035 10 mg 10mg
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Product Code. 30000035

Brand: Tocris Bioscience™ 7898/10

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Description

Inhibitor of the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS)

ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), which reduces extracellular 5-HT concentration and down-regulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 can readily cross the blood-brain barrier.
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Specifications

Chemical Name or Material N-Acetyl-L-alanyl-L-valine methyl ester
CAS 99141-91-0
Quantity 10 mg
Target SLC6A4/5-HTTLPR/Serotonin transporter
Molecular Formula C11H20N2O4
Purity 0.98
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