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Tocris Bioscience™ VX 745
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Product Code. 18075212
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18075212 50 mg 50mg
18024242 10 mg 10mg
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Product Code. 18075212 Supplier Tocris Bioscience™ Supplier No. 3915/50

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Description

Potent and selective p38α inhibitor

VX 745 is a highly potent and selective p38α/MAPK14 inhibitor, also inhibits p38β (IC50 values are 10 nM and 220 nM respectively). VX 745 blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 51-180 nM). Also reduces phosphorylation of p38MAPKα and the downstream target Hsp27, leading to vasodilation, reduces IL-1β levels and amyloid plaques in cortex and hippocampus and lowers CSF tau levels in vivo.
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Chemical Identifiers

CAS 209410-46-8
Molecular Formula C19H9Cl2F2N3OS

Specifications

Quantity 50 mg
Formula Weight 436.26
Purity >98%
Molecular Weight (g/mol) 436.26
Chemical Name or Material VX 745
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