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STEMCELL Technologies Tivantinib

Product Code. 17140232
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 17140232

Brand: STEMCELL Technologies undefined

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Description

HGF pathway inhibitor; Inhibits MET

  • Tivantinib is a staurosporine derivative which binds to inactive, dephosphorylated MET receptor tyrosine kinase, in a manner that is not competitive with ATP (Munshi et al.; Eathiraj et al.) It is selective for MET (Ki ≅ 355 nM) in a screen of 230 kinases (Munshi et al.) It also shows cytotoxic activity which is distinct from its inhibition of MET (Basilico et al.; Katayama et al.) It has also been shown to bind directly to the colchicine binding pocket of tubulin, thereby reducing tubulin polymerization (Aoyama et al.)

Specifications

CAS 905854-02-6
Synonym ARQ 197
Quantity 10 mg
Molecular Formula C23H19N3O2
Purity ≥98%
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