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  5. Tocris Bioscience™ Sonidegib

Tocris Bioscience™ Sonidegib
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Product Code. p-7249498
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
Product Code. Quantity unitSize
18746926 50 mg 50mg
18736376 10 mg 10mg
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Product Code. 18746926

Brand: Tocris Bioscience™ 7826/50

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Description

Potent Smoothened receptor antagonist

Sonidegib is a potent Smoothened (Smo) receptor antagonist (IC50 values are 1.3 nM and 2.5 nM at mouse and human receptors, respectively). Inhibits growth of a variety of tumor types including basal cell carcinoma, small cell lung cancer and medulloblastoma. Sonidegib inhibits Hh pathway in CD34+ chronic myeloid leukemia cells; it reduces both the number of cells and self-renewal ability. Brain penetrant and orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
CAS 956697-53-3
Quantity 50 mg
Target Smoothened
Molecular Formula C26H26F3N3O3
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