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STEMCELL Technologies SIS3

Product Code. 17120302
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Quantity:
1 mg
500 μg
Unit Size:
1mg
500µg
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17120302 500 μg 500µg
17130302 1 mg 1mg
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Product Code. 17120302 Supplier STEMCELL Technologies Supplier No. 73962

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Description

Activin/NODAL/TGF-β pathway inhibitor; Inhibits SMAD3

  • SIS3 (specific inhibitor of SMAD3) is a cell-permeable selective inhibitor of transforming growth factor β1 (TGF-β1)-dependent SMAD3 phosphorylation (IC50 = 3 μM) and SMAD3-mediated cellular signaling (Jinnin et al.) SIS3 has no effect on SMAD2, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), or phosphoinositide 3-kinases
  • Facilitates the production of anterior ectoderm from mouse induced pluripotent stem cells (Oshima et al.)
  • Inhibits myofibroblast differentiation of normal human dermal fibroblasts (Jinnin et al.)

Specifications

CAS 1009104-85-1
Synonym Smad3 Inhibitor
Quantity 500 μg
Molecular Formula C28H27N3O3
Purity ≥98%
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