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STEMCELL Technologies SAHA

Product Code. 17110292
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Quantity:
100 mg
Unit Size:
100mg
Product Code. Quantity unitSize
17110292 100 mg 100mg
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Product Code. 17110292

Brand: STEMCELL Technologies 73902

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Description

Epigenetic modifier; Inhibits HDAC1 and HDAC3

  • SAHA (suberoylanilide hydroxamic acid) is a potent inhibitor of class I and class II histone deacetylases (HDACs)
  • This compound inhibits the activities of HDAC1 and HDAC3 (IC50 = 10 nM and 20 nM, respectively; Richon et al.) SAHA exhibits antiproliferative properties and can cause cell cycle arrest at G1 (Marks & Breslow)
  • Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.)
  • Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.)
  • SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.)

Specifications

CAS 149647-78-9
Synonym Suberoylanilide hydroxamic acid; Vorinostat
Quantity 100 mg
Molecular Formula C14H20N
Purity ≥98%
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