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  5. STEMCELL Technologies Rolipram

STEMCELL Technologies Rolipram

Product Code. 17170212
Encompass_Preferred
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
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Product Code. 17170212

Brand: STEMCELL Technologies 73384

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This item is not returnable. View return policy

Description

cAMP pathway activator; Inhibits type 4 cyclic nucleotide phosphodiesterases (PDE4)

  • Rolipram is a cell-permeable, selective inhibitor of Type 4 cyclic nucleotide phosphodiesterases (PDE4), which mediate cyclic AMP (cAMP) degradation
  • Rolipram preferably inhibits PDE4 isoform A (IC50 = 3 nM) over other isoforms such as B and D (IC50 = 130 and 240 nM respectively; MacKenzie & Houslay)
  • It inhibits interferon (IFN)-γ stimulated phosphorylation of p38 mitogen-activated protein (MAP) kinase through PDE4B and/or PDE4D isoform inhibition (MacKenzie & Houslay)

Specifications

CAS 61413-54-5
Synonym SB 95952; ZK 62711
Quantity 25 mg
Molecular Formula C16H21NO3
Purity ≥98%
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