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STEMCELL Technologies RepSox

Product Code. 17170272
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Quantity:
1 mg
10 mg
Unit Size:
10mg
1mg
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Product Code. 17170272

Brand: STEMCELL Technologies 73792

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This item is not returnable. View return policy

Description

Activin/Nodal/TGFβ pathway inhibitor; Inhibits ALK5

  • RepSox is a cell-permeable, selective inhibitor of the TGF-β type 1 receptor (TGFβRI) ALK5 (IC50 = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively; Gellibert et al.) This inhibitor demonstrates less potent activity (IC50 > 16 μM) against 9 related kinases, including p38 MAPK and GSK3 (Gellibert et al.)
  • Enhances reprogramming of mouse embryonic fibroblasts (MEFs) that have been transduced with OCT4, KLF4, and c-MYC (Ichida et al.; Subramanyam et al.)
  • Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, VaLproic Acid, Forskolin, SP600125, Gö6983 and Y-27632 (Hu et al.) DIFFERENTIATION
  • Alone or in combination with Forskolin, Dexamethasone, and Nicotinamide, induces differentiation of human pancreatic progenitor cells into insulin-producing cells (Kunisada et al.; Rezania et al.)

Specifications

CAS 446859-33-2
Synonym ALK5 inhibitor II; E-616452; SJN 2511
Quantity 1 mg
Molecular Formula C17H13N5
Purity ≥98%
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