missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ PFK 15

Tocris Bioscience™ PFK 15
GREENER_CHOICE

Product Code. 18788219
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
This item is not returnable. View return policy

Product Code. 18788219

Brand: Tocris Bioscience™ 5339/10

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Selective PFKFB3 inhibitor

PFK 15 is an originally reported to be a selective PFKFB3 inhibitor (IC50 = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay. Selective for PFKFB3 over a panel of 96 kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material PFK 15
CAS 4382-63-2
Synonym 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Quantity 10 mg
Solubility Soluble to 100mM in DMSO
Molecular Formula C17H12N2O
Formula Weight 260.29
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >99%

Research Use Only. Not For Human or Veterinary Use

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.