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STEMCELL Technologies Purvalanol A

Product Code. 17150272
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 17150272

Brand: STEMCELL Technologies 73774

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Description

Cyclin/CDK pathway inhibitor; Inhibits CDKs

  • Purvalanol A is a cell-permeable, potent, and selective inhibitor of cyclin-dependent kinases (CDKs)
  • CDKs and cyclins form a stoichiometric complex which is necessary for the CDK subunit to gain its protein kinase activity
  • It has been shown that these CDK/cyclin complexes play a key role in initiating G2/M transitions of the cell cycle (Jackman & Pines)
  • Purvalanol A acts through competitive inhibition of ATP binding, to inhibit CDK1/cyclin B (IC50 = 4 nM), CDK2/cyclin A (IC50 = 70 nM), CDK2/cyclin E (IC50 = 35 nM), CDK4/cyclin D1 (IC50 = 850 nM) and CDK5-p35 (IC50 = 75 nM; Bain et al.; Gray et al.), thereby arresting cells in G1 and G2
  • Inhibits proliferation in exponentially growing cancer cell lines and reversibly arrests synchronised cells in G1 and G2 phase of cell cycle (Villerbu et al.)
  • Induces apoptosis in MCF-7 estrogen receptor positive breast cancer cells (Obakan et al.)
  • Suppresses cancer progression associated with Src up-regulation by the coordinated inhibition of cell cycle progression and tyrosine kinase signaling (Hikita et al.)

Specifications

CAS 212844-53-6
Synonym NG 60
Quantity 10 mg
Molecular Formula C19H25ClN6O
Purity ≥98%
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