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Tocris Bioscience™ Pladienolide B
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Product Code. 18747136
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Quantity:
500 μg
Unit Size:
500µg
Product Code. Quantity unitSize
18747136 500 μg 500µg
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Product Code. 18747136

Brand: Tocris Bioscience™ 6070/500U

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Description

mRNA splicing inhibitor; antitumor

Pladienolide B is a mRNA splicing inhibitor that decreases splicing capacity up to 75% in vitro. Pladienolide B directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Pladienolide B arrests the cell cycle in G1 and G2/M phases and displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM). Cell permeable and active in vivo.
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Specifications

Chemical Name or Material Pladienolide B
CAS 445493-23-2
Synonym (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Quantity 500 μg
Solubility Soluble to 1mg/mL in DMSO
Molecular Formula C30H48O8
Formula Weight 536.7
Physical Form Film
Color Colorless
Product Type Bioactive Small Molecule
Purity >95%
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