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  5. STEMCELL Technologies PD98059

STEMCELL Technologies PD98059

Product Code. 17180032
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Quantity:
1 mg
5 mg
Unit Size:
1mg
5mg
Product Code. Quantity unitSize
17180032 5 mg 5mg
17170032 1 mg 1mg
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Product Code. 17180032

Brand: STEMCELL Technologies 72174

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Description

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

  • PD98059 is a selective, cell permeable inhibitor of the MEK/ERK pathway that acts by preventing the activation of MEK1 (IC50 = 2 - 7 μM) and MEK2 (IC50 = 50 μM) by upstream kinases
  • It does not inhibit activated MEK, or the p38 MAPK pathway
  • (Alessi et al.), Davies et al.), Dudley et al.)
  • Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Burdon et al.), Qi et al.)
  • Permits derivation of mouse ES cells from the refractory CBA mouse strain (Buehr and Smith)
  • Blocks the differentiation of mouse ES cells (Burdon et al.)
  • Enhances adipogenic differentiation and blocks osteogenic differentiation of human mesenchymal stem cells (Jaiswal et al.)
  • Decreases number of AML blast colonies with minimal effect on normal hematopoietic progenitors (Milella et al.)

Specifications

CAS 167869-21-8
Quantity 5 mg
Molecular Formula C16H13NO3
Purity ≥98%
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