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Tocris Bioscience™ MK 2206 dihydrochloride
Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor
1600.00 NOK - 5900.00 NOK
Specifications
| Chemical Name or Material | 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride |
|---|---|
| CAS | 1032350-13-2 |
| Target | Akt (Protein Kinase B) Inhibitors |
| Molecular Formula | C25H21N5O.2HCl |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
30000034
|
Tocris Bioscience™
7850/10 |
10 mg |
1600.00 NOK
10mg |
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|
30000037
|
Tocris Bioscience™
7850/50 |
50 mg |
5900.00 NOK
50mg |
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Description
MK 2206 dihydrochloride is a potent and selective allosteric Akt inhibitor (IC50 values are 5 nM, 12 nM, and 65 nM for Akt1, Akt2, and Akt3, respectively). MK 2206 requires the Pleckstrin homology domain for its activity, and exhibits no inhibitory activity in a panel of 250 tested protein kinases. MK 2206 induces growth inhibition of different cancer cell lines (IC50 in the range 3.4 and 28.6 μmol/L) and enhances antitumor efficacy of a range of standard chemotherapeutics. It synergistically inhibits cell proliferation of human lung and breast cancer cells in combination with Erlotinib (Cat. No. 7194) by suppressing both the Ras/Erk and PI 3-K pathways in vitro and in vivo. MK 2206 can be used to block the IL-22 - Akt signaling pathway for studying paneth cell differentiation.Specifications
| 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride | |
| Akt (Protein Kinase B) Inhibitors | |
| 0.98 |
| 1032350-13-2 | |
| C25H21N5O.2HCl |
Safety and Handling
Recommended Storage : Store at -20°C
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