missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 18014432

Tocris Bioscience™ Meclizine dihydrochloride
GREENER_CHOICE

Product Code. 18014432
Click to view available options
Quantity:
50 mg
Unit Size:
50mg
This item is not returnable. View return policy

Product Code. 18014432

Brand: Tocris Bioscience™ 4245/50

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Human pregnane X receptor agonist; H1 antagonist

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H1 receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.
TRUSTED_SUSTAINABILITY

Specifications

CAS 1104-22-9
Quantity 50 mg
Molecular Formula C25H29Cl3N2
Formula Weight 463.87
Purity >99%
Molecular Weight (g/mol) 463.871
Chemical Name or Material Meclizine dihydrochloride
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.