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STEMCELL Technologies ISCK03

Product Code. 17110272
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 17110272

Brand: STEMCELL Technologies 73734

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This item is not returnable. View return policy

Description

SCF/KIT pathway inhibitor; Inhibits KIT

  • ISCK03 (inhibitor of SCF/c-KIT) is a cell-permeable phenyl-imidazolosulfonamide compound that inhibits KIT activity
  • ISCK03 inhibits SCF-induced c-KIT phosphorylation and downstream ERK phosphorylation at a concentration of 1 - 5 μM in 501mel melanoma cells (Na et al.)
  • Causes significant decrease in blood vessel density on human lung adenocarcinoma (A549) cells irradiated with X-rays (6 Gy; Kamlah et al.)
  • Reduces cell viability and ERK1/2 phosphorylation in acute myeloid leukemia (AML)-derived cell lines (Kon et al.)

Specifications

CAS 945526-43-2
Synonym c-Kit inhibitor II; Stem cell factor/c-Kit inhibitor
Quantity 10 mg
Molecular Formula C19H21N3O2S
Purity ≥95%
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