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STEMCELL Technologies Genistein
NF-kB, AMPK, and tyrosine kinase pathway inhibitor; Inhibits tyrosine kinase, topoisomerase II and activates PPARγ
Brand: STEMCELL Technologies 72002
Additional Details : Weight : 0.05000kg
Description
- Genistein is a phytoestrogen that exhibits a wide range of biological effects
- It acts by competing for the ATP-binding site of tyrosine kinases but does not inhibit the activity of serine- and threonine-specific kinases such as cAMP-dependent protein kinase, protein kinase C, and phosphorylase kinase (Akiyama et al.) Genistein binds to and activates peroxisome proliferator-activated receptor-gamma (PPARγ) and estrogen receptors, leading to a decrease in osteogenesis and an increase in adipogenesis (Dang et al.) Genistein also binds and activates the seven-transmembrane estrogen receptor GPR30 to activate alternative estrogen signaling pathways (Thomas & Dong)
- Inhibits adipocyte differentiation in 3T3-L1 cell culture (Hwang et al.)
- Control of osteoblast and adipocyte cell fates in mouse bone marrow cells (Dang et al.)
- Inhibits growth of leukemia, lymphoma, neuroblastoma, gastric, breast, and prostate cancer cells (Sarkar & Li)
Specifications
| 446-72-0 | |
| 100 mg | |
| C15H10O5 | |
| ≥98% |