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STEMCELL Technologies Cyclic Pifithrin-Alpha (Hydrobromide)
p53 Inhibitor
Brand: STEMCELL Technologies 72062
Additional Details : Weight : 0.05000kg
Description
- Cyclic Pifthrin-Alpha is a cell-permeable and reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription
- It is a more stable and less cytotoxic analog of the non-cyclic form of pifithrin-alpha
- Cyclic Pifithrin-Alpha has also been reported to activate the aryl hydrocarbon receptor
- (Fernandez-Cruz et al.), Gary & Jensen, Komarov et al.)
- Increases efficiency of reprogramming mouse embryonic fibroblasts to induced pluripotent stem cells (Liao et al.)
- Reduces UV-induced apoptosis of mouse embryonic stem cells (Qin et al.)
- Increases the numbers of mouse hematopoietic stem and progenitor cells in vivo and in vitro, also decreases the radiation-induced death of these cells (Leonova et al.)
Specifications
| 511296-88-1 | |
| 5 mg | |
| ≥95% |
| Cyclic PFT-α; Cyclic Pifithrin-α; PFT-β; Pifithrin-β | |
| C16H16N2S · HBr |