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STEMCELL Technologies Cyclic Pifithrin-Alpha (Hydrobromide)

p53 Inhibitor

Brand:  STEMCELL Technologies 72062

Additional Details : Weight : 0.05000kg

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Product Code. 17100022

  • 1723.49 NOK / 5mg
Estimated Shipment: 03-05-2024
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Description

Description

  • Cyclic Pifthrin-Alpha is a cell-permeable and reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription
  • It is a more stable and less cytotoxic analog of the non-cyclic form of pifithrin-alpha
  • Cyclic Pifithrin-Alpha has also been reported to activate the aryl hydrocarbon receptor
  • (Fernandez-Cruz et al.), Gary & Jensen, Komarov et al.)
  • Increases efficiency of reprogramming mouse embryonic fibroblasts to induced pluripotent stem cells (Liao et al.)
  • Reduces UV-induced apoptosis of mouse embryonic stem cells (Qin et al.)
  • Increases the numbers of mouse hematopoietic stem and progenitor cells in vivo and in vitro, also decreases the radiation-induced death of these cells (Leonova et al.)
Specifications

Specifications

511296-88-1
5 mg
≥95%
Cyclic PFT-α; Cyclic Pifithrin-α; PFT-β; Pifithrin-β
C16H16N2S · HBr
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