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STEMCELL Technologies Compound E

Product Code. p-7217671
Encompass_Preferred
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Quantity:
1 mg
500 μg
Unit Size:
1mg
500µg
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Product Code. 17110302

Brand: STEMCELL Technologies 73954

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This item is not returnable. View return policy

Description

Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein

  • Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.)
  • Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.)
  • Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.)

Specifications

CAS 209986-17-4
Synonym γ-secretase inhibitor XXI
Quantity 1 mg
Molecular Formula C27H24F2N4O3
Purity ≥98%
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