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  5. STEMCELL Technologies AZD6244

STEMCELL Technologies AZD6244

Product Code. 17180152
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Product Code. 17180152 Supplier STEMCELL Technologies Supplier No. 72992

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Description

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

  • AZD6244 is a potent, highly selective inhibitor of the mitogen-activated protein kinases MEK1 (IC50 = 14 nM) and MEK2 (Kd = 530 nM; Yeh et al.; Davis et al.) It is a tight-binding noncompetitive inhibitor that does not bind in the ATP binding pocket of MEK (Huynh et al.) It also shows micromolar binding to epidermal growth factor receptor (EGFR; Davis et al.)
  • Inhibits growth of several tumor cell lines but not normal fibroblast lines, and inhibits tumor growth in a colorectal xenograft tumor model (Yeh et al.)
  • Inhibits proliferation and induces differentiation and apoptosis in multiple tumor cell lines and tumor xenograft models, especially those containing BRAF or RAS mutations (Davies et al.)
  • Inhibits proliferation of breast cancer and non-small cell lung cancer cell lines, especially those containing RAF and RAS mutations, respectively (Garon et al.)

Specifications

CAS 606143-52-6
Synonym ARRY-142886; Cl-1040; G 00039805; NSC 741O78; Selumetinib
Quantity 10 mg
Molecular Formula C17H15BrClFN4O3
Purity ≥95%
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