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  5. Tocris Bioscience™ ARN 14494

Tocris Bioscience™ ARN 14494
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Product Code. 18718176
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Product Code. 18718176 Supplier Tocris Bioscience™ Supplier No. 7134/10

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Description

Potent serine palmitoyltransferase inhibitor

ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
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Specifications

Chemical Name or Material rel-1-[1-[2-[(3 aR,6 AS)-Hexahydrocyclopenta[c]pyrrol-2(1 H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1 H-indole-5-carboxamide
CAS 1037834-43-7
Quantity 10 mg
Target Other Transferase Inhibitors
Molecular Formula C24H32N4O3
Purity 0.98
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