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  5. STEMCELL Technologies AKT Inhibitor VIII

STEMCELL Technologies AKT Inhibitor VIII

Product Code. p-7217367
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Quantity:
1 mg
10 mg
Unit Size:
10mg
1mg
Product Code. Quantity unitSize
17110152 1 mg 1mg
17120152 10 mg 10mg
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Product Code. 17110152

Brand: STEMCELL Technologies 72942

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Description

PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, and AKT3

  • AKT Inhibitor VIII is a cell-permeable, allosteric inhibitor of all three forms of the kinase AKT (AKT1, AKT2, and AKT3) with IC50 values of 58, 210, and 2,200 nM, respectively (Lindsley et al.; Calleja et al.) It displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, such as calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase (Logie et al.)
  • Sensitizes prostate tumor and cervical carcinoma cells to apoptotic stimuli (DeFeo-Jones et al.)
  • Blocks mitosis and inhibits migration of HeLa cells (Jo et al.)
  • Reduces insulin-dependent gene repression in liver cells leading to reduced insulin sensitivity (Logie et al.)

Specifications

CAS 612847-09-3
Synonym AKTi-1/2; AKT 1/2 inhibitor
Quantity 1 mg
Molecular Formula C34H29N7O
Purity ≥98%
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