missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 18717336

Tocris Bioscience™ DSRM-3716
GREENER_CHOICE

Product Code. 18717336
Click to view available options
Quantity:
50 mg
Unit Size:
50mg
This item is not returnable. View return policy

Product Code. 18717336

Brand: Tocris Bioscience™ 7414/50

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Potent and reversible SARM1 NAD hydrolase inhibitor

DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 5-Iodoisoquinoline
CAS 58142-99-7
Quantity 50 mg
Target Hydrolase Inhibitors
Molecular Formula C9H6IN
Purity 0.98
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.