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  5. STEMCELL Technologies 3-Deazaneplanocin A

STEMCELL Technologies 3-Deazaneplanocin A

Product Code. 17170052
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1 mg
500 μg
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1mg
500µg
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17180052 1 mg 1mg
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Product Code. 17170052 Supplier STEMCELL Technologies Supplier No. 72322

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Description

Epigenetic modifier; Inhibits histone EZH2 lysine methyltransferase

  • Deazaneplanocin A (DZNep) is an inhibitor of lysine methyltransferases, particularly EZH2
  • DZNep therefore acts as an epigenetic modifier, specifically inhibiting the trimethylation of Histone 3, Lysine 27, by depleting levels of EZH2
  • (Miranda et al.), Tan et al.), Tseng et al.)
  • Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, VaLproic Acid, Tranylcypromine, and E-616452, by increasing OCT4 expression at later stages of reprogramming (Hou et al.)
  • Reactivation of XIST-dependent inactive X chromosomes in human embryonic stem cells (Diaz Perez et al.)
  • Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.)
  • Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.)

Specifications

CAS 102052-95-9
Synonym DZNep; NSC 617989
Quantity 500 μg
Molecular Formula C12H14N4O3
Purity ≥97%
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