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Tocris™ Reparixin L-lysine salt

Product Code. 18796336
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10 mg
Unit Size:
10mg
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Product Code. 18796336 Supplier Tocris™ Supplier No. 6957/10

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Description

Potent CXCR1 and CXCR2 allosteric antagonist

Reparixin L-lysine salt is a potent and noncompetitive CXCR1 and CXCR2 allosteric antagonist (IC50 = 1 nM for inhibition of CXCL8-induced human polymorphonuclear cell migration). Also inhibits migration of rodent neutrophils induced by CXCL1, CXCL2, CXCL8 and CINC-1. Inhibits vascular permeability and neutrophil recruitment in in vivo models of mild and severe ischemia/reperfusion injury. Also selectively depletes cancer stem cells in human breast cancer cell lines and xenograft models.
TRUSTED_SUSTAINABILITY

Specifications

CAS 266359-93-7
Synonym Repertaxin L-lysine salt
Quantity 10 mg
Solubility Soluble to 50 mM in DMSO and to 5 mM in water with gentle warming
Molecular Formula C14H21NO3S.C6H14N2O2
Formula Weight 429.58
Product Type Antagonist
Purity 98%
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