CAS RN 923564-51-6

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Tocris Bioscience™ ABT 263

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Pricing and Availability
Specifications

Target	Bcl-2 Family Inhibitors
CAS	923564-51-6
Purity	0.98
Chemical Name or Material	4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Recommended Storage	Store at -20°C
Molecular Formula	C₄₇H₅₅ClF₃N₅O₆S₃

MedChemExpress Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	974.61
Color	White
Physical Form	Solid
Chemical Name or Material	Navitoclax
Grade	Research
SMILES	O=S(C1=CC(S(NC(C2=CC=C(N3CCN(CC4=C(CCC(C)(C4)C)C5=CC=C(Cl)C=C5)CC3)C=C2)=O)(=O)=O)=CC=C1N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)(C(F)(F)F)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	96.09%
CAS	923564-51-6
Solubility Information	DMF : ≥ 100 mg/mL (102.61 mM) ∣DMSO : 75 mg/mL (76.95 mM; Need ultrasonic)
Synonym	ABT-263
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₄₇H₅₅ClF₃N₅O₆S₃
Formula Weight	974.61

CAS RN 923564-51-6

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