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CAS RN 909910-43-6

CAS RN 909910-43-6

IUPAC Name: 3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
Synonyms: 3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)pyrazole-1-carbothioamide
Molecular Weight (g/mol): 421.52
Molecular Formula: C25H19N5S
InChi Key: HIJMSZGHKQPPJS-UHFFFAOYSA-N
SMILES: CC1=CC=CC(=N1)C1=NN(C=C1C1=C2C=CC=CC2=NC=C1)C(=S)NC1=CC=CC=C1
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1 – 4 of 4 results
1

A 83-01, Tocris Bioscience™

CAS: 909910-43-6 Molecular Formula: C25H19N5S Molecular Weight (g/mol): 421.522 InChI Key: HIJMSZGHKQPPJS-UHFFFAOYSA-N Synonym: alk5 inhibitor iv,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-yl-1h-pyrazole-1-carbothioamide,tgf-beta inhibitor a-83-01,1h-pyrazole-1-carbothioamide,3-6-methyl-2-pyridinyl-n-phenyl-4-4-quinolinyl,transforming growth factor-beta type i receptor kinase inhibitor iv,3-6-methylpyridin-2-yl-4-4-quinolyl-1-phenylthiocarbamoyl-1h-pyrazole,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-yl pyrazole-1-carbothioamide,tgfss inhibitor a-83-01,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide,3-6-methyl-2-pyridinyl-n-phenyl-4-4-quinolinyl-1h-pyrazole-1-carbothioamide PubChem CID: 16218924 IUPAC Name: 3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide SMILES: CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5

PubChem CID 16218924
CAS 909910-43-6
Molecular Weight (g/mol) 421.522
SMILES CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
Synonym alk5 inhibitor iv,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-yl-1h-pyrazole-1-carbothioamide,tgf-beta inhibitor a-83-01,1h-pyrazole-1-carbothioamide,3-6-methyl-2-pyridinyl-n-phenyl-4-4-quinolinyl,transforming growth factor-beta type i receptor kinase inhibitor iv,3-6-methylpyridin-2-yl-4-4-quinolyl-1-phenylthiocarbamoyl-1h-pyrazole,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-yl pyrazole-1-carbothioamide,tgfss inhibitor a-83-01,3-6-methylpyridin-2-yl-n-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide,3-6-methyl-2-pyridinyl-n-phenyl-4-4-quinolinyl-1h-pyrazole-1-carbothioamide
IUPAC Name 3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
InChI Key HIJMSZGHKQPPJS-UHFFFAOYSA-N
Molecular Formula C25H19N5S
2

Tocris Bioscience™ A 83-01

A 83-01 synthesized to Ancillary Material Grade

3

STEMCELL Technologies A 83-01

Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7

ENCOMPASS_PREFERRED
CAS 909910-43-6
Purity ≥95%
Molecular Formula C25H19N5S
4

A 83-01, MedChemExpress

MedChemExpress A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 421.52
Color Off-White
Physical Form Powder
Chemical Name or Material A 83-01
Grade Research
SMILES S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.0%
CAS 909910-43-6
Solubility Information DMSO : 25 mg/mL (59.31 mM; ultrasonic and warming and heat to 60°C) ∣H2O : < 0.1 mg/mL (insoluble)
Health Hazard 1 H302∣H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage -20°C, protect from light, stored under nitrogen∣The compound is unstable in solutions, freshly prepared is recommended.
Shelf Life -20°C, protect from light, stored under nitrogen∣The compound is unstable in solutions, freshly prepared is recommended.
Molecular Formula C25H19N5S
Formula Weight 421.52