CAS RN 630124-46-8

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AST 487, MedChemExpress

MedChemExpress AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.

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Molecular Weight (g/mol)	529.56
Color	White
Physical Form	Solid
Chemical Name or Material	AST 487
Grade	Research
SMILES	O=C(NC1=CC=C(OC2=NC=NC(NC)=C2)C=C1)NC3=CC=C(CN4CCN(CC)CC4)C(C(F)(F)F)=C3
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.2%
CAS	630124-46-8
Solubility Information	DMSO : ≥ 100 mg/mL (188.84 mM)
Synonym	NVP-AST 487
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₆H₃₀F₃N₇O₂
Formula Weight	529.56

CAS RN 630124-46-8

CAS RN 630124-46-8

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