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TIM3 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4C4G3, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 60355-1-IG-150UL
Additional Details : Weight : 0.00010kg
Description
TIM3 is a 280 aa membrane protein with a calculated molecular weight of 33 kDa, the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3.
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.Specifications
| TIM3 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P0C0K5, Q8TDQ0, Q8VIM0 | |
| Havcr2 | |
| TIM3 Fusion Protein Ag16901 | |
| 150 μL | |
| Primary | |
| Human, Mouse, Porcine, Rat | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| 4C4G3 | |
| Unconjugated | |
| HAVCR2 | |
| CD366, HAVcr 2, HAVCR2, KIM 3, T cell membrane protein 3, Tim 3, TIM3, TIM-3, TIMD 3, TIMD3 | |
| Mouse | |
| Protein G | |
| RUO | |
| 100522045, 171285, 363578, 84868 | |
| -20°C | |
| Liquid |