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TERF2IP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 14595-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16883304

  • 1281.92 NOK / 20µL
Estimated Shipment: 14-12-2022
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Description

Description

Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length(1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
Specifications

Specifications

TERF2IP
Polyclonal
Unconjugated
TERF2IP
DRIP5, hRap1, RAP1, RAP1 homolog, TERF2IP
Rabbit
Antigen Affinity Chromatography
RUO
307861, 54386, 57321
-20°C
Liquid
Immunofluorescence, Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin)
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q5EAN7, Q91VL8, Q9NYB0
Terf2ip
TERF2IP Fusion Protein Ag6130
20 μL
Primary
Mouse, Human, Rat
Antibody
IgG
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