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Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Product Code. 10220264 Shop All Thermo Scientific Products
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Quantity:
50 mg
Unit Size:
50mg
Product Code. Quantity unitSize
10220264 50 mg 50mg
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Product Code. 10220264

Brand: Thermo Scientific™ 21857

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Description

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.

Thermo Scientific™ Pierce SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

  • Widely used in immunochemistry; conjugates used in drug carrier systems, antibody production and enzyme immunoassays
  • Can be used as a protein thiolation reagent
  • Reactive groups: NHS ester and pyridyldisulfide
  • Reactive toward: amino and sulfhydryl groups
TRUSTED_SUSTAINABILITY

Specifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable By Thiols
Description SPDP
Molecular Weight (g/mol) 312.36
PEGylated No
Spacer Arm Length 6.8 Å
Content And Storage Upon receipt store at -20°C protected from moisture.
Cell Permeability Yes
Shipping Condition Ambient
Product Line Pierce
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety NHS Ester, Pyridyldisulfide
Spacer Short (<10 Å)
Form Powder
Quantity 50 mg
Solubility DMF, DMSO
Format Standard, Premium-grade
Water Soluble No
Product Type Crosslinker
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Safety and Handling

compliance-icons
Product Identifier
  • SPDP (succinimidyl 3-(2-pyridyldithio)propionate)
 Signal Word
  • Warning
 Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
 Precautionary Statement
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P264-Wash hands thoroughly after handling.
  • P271-Use only outdoors or in a well-ventilated area.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
  • P362+P364-Take off contaminated clothing and wash it before reuse.
  • P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
 Supplemental information
  • MIXTURE LIST-Contains : 1-[1-Oxo-3-(2-pyridyldithio)pro poxy]pyrrolidine-2,5-dione

For Research Use Only. Not for use in diagnostic procedures.

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