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Phospho-Ask1 (Ser83) Recombinant Rabbit Monoclonal Antibody (Ask1S83-G4), PE, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Thermo Scientific MA536974

Additional Details : Weight : 0.01000kg

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Product Code. 17106568

  • 4995.00 NOK / Pack of 100
Estimated Shipment: 21-06-2024
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Description

Description

MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
Specifications

Specifications

Phospho-Ask1 (Ser83)
Monoclonal
PE
MAP3K5
7420452D20Rik; apoptosis signal regulating kinase 1; apoptosis signal-regulating kinase 1; ASK; ASK 1; ASK1; ASK-1; EC 2.7.11.25; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; Map3k5; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; Mekk5; mitogen activated protein kinase kinase kinase 5; mitogen-activated protein kinase kinase kinase 5; RGD1306565; RP3-325F22.4
Rabbit
Protein A/G
RUO
26408, 365057, 4217
4° C
Liquid
Flow Cytometry
Ask1S83-G4
PBS with 0.20% BSA and 0.09% sodium azide
O35099, Q99683
MAP3K5
A synthetic phospho-peptide corresponding to residues surrounding Ser83 of human phospho Ask1.
100 Tests
Primary
Human, Mouse, Rat
Antibody
IgG κ
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