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NOVA2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
1710.33 NOK - 4836.10 NOK
Specifications
| Antigen | NOVA2 |
|---|---|
| Concentration | 0.21 mg/mL |
| Applications | Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
16896425
|
Proteintech
55002-1-AP-20UL |
20 μL |
1710.33 NOK
20µL |
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|
16886425
|
Proteintech
55002-1-AP-150UL |
150 μL |
4836.10 NOK
150µL |
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Description
The antibody is specific to NOVA2.
Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder thought to be mediated by an autoimmune attack against onconeural disease antigens that are expressed by gynecologic or lung tumors and by neurons. Nova-1 and -2 are both POMA disease antigens. The autoimmune attack against Nova-2 in POMA patients results in latent cancer, reduced inhibitory control of movements, and dementia. Nova-2 is closely related to Nova-1, and is expressed at high levels in neurons during development and at lower levels in the adult lung. In the postnatal mouse brain, Nova-2 is expressed in a pattern that is largely reciprocal with Nova-1, including high levels of Nova-2 expression in the neocortex and hippocampus. Both Novas are RNA binding proteins, and Nova-2 binds RNA with high affinity and with sequence specificity that differs from Nova-1. They regulate neuronal pre-messenger RNA splicing by directly binding to RNA. Nova-2 target genes function either in the synapse or in axon guidance indicating that Nova-2 is a major regulator of synaptic function.Specifications
| NOVA2 | |
| Immunoprecipitation, Western Blot | |
| Unconjugated | |
| Rabbit | |
| Rat, Mouse, Human | |
| Q9UNW9 | |
| 292681, 384569, 4858 | |
| Peptide | |
| Primary | |
| -20°C | |
| NOVA2 |
| 0.21 mg/mL | |
| Polyclonal | |
| Liquid | |
| RUO | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| ANOVA, NOVA2, NOVA3, RNA binding protein Nova 2 | |
| Nova2 | |
| IgG | |
| Antigen Affinity Chromatography | |
| Antibody |
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