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Integrin alpha 4 beta 7 (LPAM-1) Monoclonal Antibody (DATK32 (DATK-32)), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 16-5887-38
This item is not returnable.
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Description
The DATK32 MAb binds to a combinatorial epitope of mouse LPAM-1 (alpha4beta7), which is a heterodimer of the the 154 kDa alpha4 subunit and the 130 kDa beta7 subunit. In mouse, the beta7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 MAb has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.
Integrin alpha 4 beta 7 (LPAM-1) Monoclonal antibody specifically detects Integrin alpha 4 beta 7 (LPAM-1) in Mouse samples. It is validated for Flow Cytometry, Functional Assay
Specifications
| Integrin alpha 4 beta 7 (LPAM-1) | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| P26011, Q00651 | |
| Rat | |
| 5 mg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a κ |
| Flow Cytometry, Functional Assay | |
| DATK32 (DATK-32) | |
| Functional Grade | |
| Itga4 | |
| CD49 antigen-like family member D; CD49d; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin beta 7; Integrin beta-7; Integrin beta-P; Itga4; Itga4B; Itgb7; LPAM subunit alpha; Ly69; Lymphocyte Peyer patch adhesion molecules subunit alpha; M290 IEL antigen; VLA; VLA 4; VLA-4 receptor, alpha 4 subunit; VLA4 subunit alpha; VLA-4 subunit alpha | |
| Affinity chromatography | |
| RUO | |
| 16401, 16421 | |
| 4° C | |
| Liquid |