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  6. Integrin alpha 4 beta 7 (LPAM-1) Monoclonal Antibody (DATK32 (DATK-32)), Functional Grade, eBioscience™, Invitrogen™

Integrin alpha 4 beta 7 (LPAM-1) Monoclonal Antibody (DATK32 (DATK-32)), Functional Grade, eBioscience™, Invitrogen™

Product Code. p-7218523
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17101342 5 mg 5mg
17181332 25 mg 25mg
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Product Code. 17101342 Supplier Affymetrix eBioscience Supplier No. 16588738

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Description

Rat Monoclonal Antibody

The DATK32 MAb binds to a combinatorial epitope of mouse LPAM-1 (alpha4beta7), which is a heterodimer of the the 154 kDa alpha4 subunit and the 130 kDa beta7 subunit. In mouse, the beta7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 MAb has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.

Integrin alpha 4 beta 7 (LPAM-1) Monoclonal antibody specifically detects Integrin alpha 4 beta 7 (LPAM-1) in Mouse samples. It is validated for Flow Cytometry, Functional Assay
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin alpha 4 beta 7 (LPAM-1)
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
Clone DATK32 (DATK-32)
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Itga4
Gene Accession No. P26011, Q00651
Gene Alias CD49 antigen-like family member D; CD49d; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin beta 7; Integrin beta-7; Integrin beta-P; Itga4; Itga4B; Itgb7; LPAM subunit alpha; Ly69; Lymphocyte Peyer patch adhesion molecules subunit alpha; M290 IEL antigen; VLA; VLA 4; VLA-4 receptor, alpha 4 subunit; VLA4 subunit alpha; VLA-4 subunit alpha
Host Species Rat
Purification Method Affinity chromatography
Quantity 5 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16401, 16421
Target Species Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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