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ACROBiosystems Human TRAIL / TNFRSF10 Protein, Mouse IgG2a Fc Tag

Brand:  ACROBiosystems TRL-H5259-1mg

Additional Details : Weight : 0.00010kg

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Product Code. 16448129

  • 32169.11 NOK / 1mg
Estimated Shipment: 19-01-2023
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Description

Description

TRAIL, also known as TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A and TNF superfamily member 10. The TRAIL gene as a drug target, induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation.

This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 46.4 kDa. The protein migrates as 47-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_003801.1
46.4 kDa
1 mg
Val 114 - Gly 281
Apo-2 L,TRAIL,CD253,TNFSF10,Apo-2 ligand
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human TRAIL, Mouse IgG2a Fc Tag (TRL-H5259) is expressed from human 293 cells (HEK293). It contains AA Val 114 - Gly 281 (Accession # P50591-1).
-20°C
TRAIL
Mouse IgG Fc Tag
Less than 0.1 EU / µg by the LAL method.
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