missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Human MERTK / Mer Protein, His Tag

Brand:  ACROBiosystems MEK-H52H6-1mg

Additional Details : Weight : 0.00010kg

 View more versions of this product

Product Code. 16447869

  • 27609.71 NOK / 1mg
Estimated Shipment: 19-01-2023
to see stock.

Please to purchase this item. Need a web account? Register with us today!


Description

Description

Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.5 kDa. The protein migrates as 70-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_006334.2
54.5 kDa
1 mg
Ala 21 - Ile 505
MERTK,Mer
Unconjugated
PBS, pH7.4
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Human MERTK, His Tag (MEK-H52H6) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Ile 505 (Accession # Q12866-1).
-20°C
MERTK
His Tag
Less than 1.0 EU / µg by the LAL method.
Enzymes
Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers