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ACROBiosystems Human MERTK / Mer Protein, His Tag

4540.76 NOK - 33298.92 NOK

Specifications

Accession Number NP_006334.2
Molecular Weight (g/mol) 54.5 kDa
Source Human MERTK, His Tag (MEK-H52H6) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Ile 505 (Accession # Q12866-1).
Immunogen Ala 21 - Ile 505
Storage Requirements -20°C
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16447869
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ACROBiosystems
MEK-H52H6-1MG
1 mg
33298.92 NOK
1mg
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16437869
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ACROBiosystems
MEK-H52H6-100UG
100 μg
4540.76 NOK
100µg
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Estimated Shipment: 11-04-2024
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Description

Description

Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.5 kDa. The protein migrates as 70-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_006334.2
Human MERTK, His Tag (MEK-H52H6) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Ile 505 (Accession # Q12866-1).
-20°C
MERTK
Human
PBS, pH7.4
HEK293
Enzymes
54.5 kDa
Ala 21 - Ile 505
MERTK,Mer
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>90% as determined by SDS-PAGE
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