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ACROBiosystems Human MERTK / Mer Protein, His Tag
4540.76 NOK - 33298.92 NOK
Specifications
Accession Number | NP_006334.2 |
---|---|
Molecular Weight (g/mol) | 54.5 kDa |
Source | Human MERTK, His Tag (MEK-H52H6) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Ile 505 (Accession # Q12866-1). |
Immunogen | Ala 21 - Ile 505 |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16447869
|
ACROBiosystems
MEK-H52H6-1MG |
1 mg |
33298.92 NOK
1mg |
Estimated Shipment: 11-04-2024 Log in to see stock. |
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16437869
|
ACROBiosystems
MEK-H52H6-100UG |
100 μg |
4540.76 NOK
100µg |
Estimated Shipment: 11-04-2024 Log in to see stock. |
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Description
Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.5 kDa. The protein migrates as 70-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
NP_006334.2 | |
Human MERTK, His Tag (MEK-H52H6) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Ile 505 (Accession # Q12866-1). | |
-20°C | |
MERTK | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Enzymes |
54.5 kDa | |
Ala 21 - Ile 505 | |
MERTK,Mer | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |