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Cytiva™ HiScreen™ Column with MabSelect™ VL Protein L Resin

These HiScreen™ columns contain Protein L resin for affinity capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain.

Brand:  Cytiva™ 17542015

Product Code. 17887764

  • 12365.00 NOK / 4.70mL
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Description

Description

As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.

Redesigned protein L ligand MabSelect™ VL protein L resin showed a two-fold increase in binding capacity compared to Cytiva™ Capto™ L chromatography resin. This higher capacity provides productivity advantages in research and biomanufacturing.

  • A redesigned protein L ligand captures antibody Fabs, bispecifics, and other variants containing a kappa light chain with high binding capacity and improved alkaline stability
  • High dynamic binding capacity for efficient capture of target molecules
  • Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents
  • Provides good resolution for product-related impurities in the capture of bispecific antibodies
  • Convenient for method optimization and parameter screening enabled by the 10 cm bed height for efficient chromatography process development
TRUSTED_SUSTAINABILITY
Specifications

Specifications

70 mg Human IgG/mL Resin at 6 min. Residence Time, 60 mg Human IgG/mL Resin at 4 min. Residence Time
0.3 in.
<300 cm/hr.
60 μm
1 Column
Antibody
Chromatography Column
Affinity
4.7 mL
7.7 mm
3 bar
HiScreen™ MabSelect™
Antibody Affinity Chromatography
Pre-packed Column
100 mm
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