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HFE2 Monoclonal Antibody (C5), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA543774
Additional Details : Weight : 0.01000kg
Description
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.Specifications
| HFE2 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300 | |
| Q6ZVN8, Q8N7M5 | |
| HFE2 | |
| Lys234-Ser416 (Accession Q6ZVN8), with N-terminal His Tag | |
| 20 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG2b κ |
| Immunohistochemistry (Paraffin), Western Blot | |
| C5 | |
| Unconjugated | |
| HFE2 | |
| 2310035L15Rik; 5230400G09Rik; AI414844; AI789733; DL M; DL-M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile); hemochromatosis type 2 (juvenile) (human homolog); hemochromatosis type 2 protein; Hemochromatosis type 2 protein homolog; hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; HFE2; HFE2A; HJV; JH; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C; RGMC | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 148738, 310681 | |
| -20°C | |
| Liquid |