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Geldanamycin, 98+%, Thermo Scientific™
Benzoquinoid antibiotic that inhibits pp60src tyrosine kinase
POA
Chemical Identifiers
| CAS | 30562-34-6 |
|---|---|
| Molecular Formula | C29H40N2O9 |
| Molecular Weight (g/mol) | 560.644 |
| MDL Number | MFCD00274570 |
| InChI Key | QTQAWLPCGQOSGP-KDFVLELPSA-N |
| Synonym | NSC 122750; U-29135 |
| PubChem CID | 133688416 |
| IUPAC Name | [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
| SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15405649
|
Thermo Scientific Alfa Aesar
J63397.MB |
25mg |
POA
25mg |
N/A | Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
15415649
|
Thermo Scientific Alfa Aesar
J63397.MC |
100mg |
POA
100mg |
N/A | Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
15425649
|
Thermo Scientific Alfa Aesar
J63397.MD |
250mg |
POA
250mg |
N/A | Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Beskrivelse
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
ApplicationsGeldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.
Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
Kemiske identifikatorer
| 30562-34-6 | |
| 560.644 | |
| QTQAWLPCGQOSGP-KDFVLELPSA-N | |
| 133688416 | |
| CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC |
| C29H40N2O9 | |
| MFCD00274570 | |
| NSC 122750; U-29135 | |
| [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
Tekniske data
| 30562-34-6 | |
| C29H40N2O9 | |
| NSC 122750; U-29135 | |
| QTQAWLPCGQOSGP-KDFVLELPSA-N | |
| [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate | |
| 133688416 | |
| ≥99% |
| Yellow to Orange | |
| MFCD00274570 | |
| Soluble in dimethyl sulfoxide at 100mg/mL. | |
| CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC | |
| 560.644 | |
| 560.64 | |
| Geldanamycin |
Sikkerhed og håndtering
missing translation for 'rtecsNumber' : LX8920000
missing translation for 'tsca' : No
Anbefalet opbevaring : Store at -20°C
RUO – Research Use Only
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