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Fc Receptor Binding Inhibitor Polyclonal Antibody, Functional Grade, eBioscience™, Invitrogen™
Polyclonal Antibody
Brand: Affymetrix eBioscience 16-9161-025
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Description
The human FcgammaR-binding inhibitor can be used to inhibit the non-specific Fc-gamma receptor (FcgammaR)-mediated binding of mouse monoclonal antibodies used for flow cytometric analysis of human tissue. Four different classes of Fcgamma receptors have been identified: FcgammaRI (CD64), FcgammaRII (CD32), and FcgammaRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcgammaR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcgammaR varies depending on the isotype of the MAb. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcgammaRs.
Fc Receptor Binding Inhibitor Polyclonal antibody specifically detects Fc Receptor Binding Inhibitor in Human samples. It is validated for Control, Flow Cytometry, Functional Assay
Specifications
| Fc Receptor Binding Inhibitor | |
| Polyclonal | |
| Functional Grade | |
| Fc blocking; FcR BI; FcR Inhibitor | |
| 25 mg | |
| Primary | |
| 4° C | |
| Liquid |
| Flow Cytometry, Functional Assay | |
| 20 μL/Test | |
| PBS with no preservative; pH 7.2 | |
| Affinity chromatography | |
| RUO | |
| Human | |
| Antibody |
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