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Doxorubicin hydrochloride, Thermo Scientific™
Doxorubicin hydrochloride, CAS # 25316-40-9, is the hydrochloride salt of doxorubicin, isolated from the bacterium Streptomyces peucetius, and is considered to be an anthracycline antibiotic with antineoplastic activity.
2548.65 NOK - 5617.65 NOK
Kemiska identifierare
| CAS | 25316-40-9 |
|---|---|
| Molecular Formula | C27H30ClNO11 |
| Molecular Weight (g/mol) | 579.98 |
| MDL Number | MFCD00077757,MFCD00077757,MFCD00941448 |
| InChI Key | MWWSFMDVAYGXBV-FGBJBKNOSA-N |
| Synonym | doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs |
| PubChem CID | 129626538 |
| IUPAC Name | hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride |
| SMILES | [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O |
| Produktkod | Brand | Quantity | Pris | Kvantitet och tillgänglighet | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktkod | Brand | Quantity | Pris | Kvantitet och tillgänglighet | |||||
|
15476139
|
Thermo Scientific Alfa Aesar
J64000.MA |
10mg |
 3440.00 NOK 2548.65 NOK / 10mg Save 891.35 NOK 25% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
15486139
|
Thermo Scientific Alfa Aesar
J64000.MF |
50mg |
7560.00 NOK 5617.65 NOK / 50mg Save 1942.35 NOK 25% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Beskrivning
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
- Doxorubicin hydrochloride, isolated from the bacterium Streptomyces peucetius, is an anthracycline antibiotic with antineoplastic activity and is related to daunorubicin
- It can intercalate between base pairs in the DNA helix preventing DNA replication
- It also inhibits the nucleic acid synthesis and can induce apoptosis
- It can inhibit DNA topoisomerase II, resulting in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication, and prevents nucleotide strand ligation after double-strand breakage
- Doxorubicin hydrochloride forms oxygen free radicals that result in cytotoxicity and lead to the lipid peroxidation of cell membrane lipids
Application
- This compound displays a fluorescent property allowing the measurement of drug efflux pump activity and examining the role of subcellular organelles (Golgi complex and lysosome) in the sequestration of drugs
- It has been used in cell viability assays
- It is used as a drug in polymeric PLGA-based microparticulate drug delivery and to develop in vitro doxorubicin-resistant HepG2 cells (HepG2-DR) and K562 cells (K562-DR)
- It is a substrate of the MRP1 transporter
Kemiska identifierare
| 25316-40-9 | |
| 579.98 | |
| MWWSFMDVAYGXBV-FGBJBKNOSA-N | |
| 129626538 | |
| [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O |
| C27H30ClNO11 | |
| MFCD00077757,MFCD00077757,MFCD00941448 | |
| doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs | |
| hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride |
Specifikationer
| 25316-40-9 | |
| MFCD00077757,MFCD00077757,MFCD00941448 | |
| 14,3439 | |
| Soluble in water. | |
| [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O | |
| 579.98 | |
| 579.99 |
| C27H30ClNO11 | |
| 4229251 | |
| doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs | |
| MWWSFMDVAYGXBV-FGBJBKNOSA-N | |
| hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride | |
| 129626538 | |
| Doxorubicin hydrochloride |
Säkerhet och hantering
GHS H Statement
H350-H302
May cause cancer.
Harmful if swallowed.
P201-P202-P261-P264b-P270-P271-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P330-P332+P313-P362-P501c
H302-H315-H318-H335-H340-H350-H361fd
missing translation for 'einecsNumber' : 246-818-3
missing translation for 'rtecsNumber' : QI9295900
missing translation for 'tsca' : No
Rekommenderad förvaring : Ambient temperatures
Produktbeteckning
Signalord
Riskkategorier
Faroangivelser
Skyddsangivelse
Kompletterande information
- Doxorubicin hydrochloride
Signalord
- Danger
Riskkategorier
- Acute toxicity Category 4
- Serious eye damage/eye irritation Category 1
- Germ cell mutagenicity Category 1A
- Reproductive toxicity Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
Faroangivelser
- H302-Harmful if swallowed.
- H315-Causes skin irritation.
- H318-Causes serious eye damage.
- H335-May cause respiratory irritation.
- H340-May cause genetic defects.
- H361fd-Suspected of damaging fertility. Suspected of damaging the unborn child.
Skyddsangivelse
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P310-Immediately call a POISON CENTER/doctor/.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
Kompletterande information
- MIXTURE LIST-Contain: Doxorubicin hydrochloride
RUO – Research Use Only
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Produkttitel
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