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Doxorubicin hydrochloride, Thermo Scientific™
Doxorubicin hydrochloride, CAS # 25316-40-9, is the hydrochloride salt of doxorubicin, isolated from the bacterium Streptomyces peucetius, and is considered to be an anthracycline antibiotic with antineoplastic activity.
Marca: Thermo Scientific Alfa Aesar J64000.MA
2408.00 NOK valid until 2026-03-27
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| Quantity | 10mg |
|---|
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Descripción
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
- Doxorubicin hydrochloride, isolated from the bacterium Streptomyces peucetius, is an anthracycline antibiotic with antineoplastic activity and is related to daunorubicin
- It can intercalate between base pairs in the DNA helix preventing DNA replication
- It also inhibits the nucleic acid synthesis and can induce apoptosis
- It can inhibit DNA topoisomerase II, resulting in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication, and prevents nucleotide strand ligation after double-strand breakage
- Doxorubicin hydrochloride forms oxygen free radicals that result in cytotoxicity and lead to the lipid peroxidation of cell membrane lipids
Application
- This compound displays a fluorescent property allowing the measurement of drug efflux pump activity and examining the role of subcellular organelles (Golgi complex and lysosome) in the sequestration of drugs
- It has been used in cell viability assays
- It is used as a drug in polymeric PLGA-based microparticulate drug delivery and to develop in vitro doxorubicin-resistant HepG2 cells (HepG2-DR) and K562 cells (K562-DR)
- It is a substrate of the MRP1 transporter
Identificadores de productos químicos
| 25316-40-9 | |
| 579.98 | |
| MWWSFMDVAYGXBV-FGBJBKNOSA-N | |
| 129626538 | |
| [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O |
| C27H30ClNO11 | |
| MFCD00077757,MFCD00077757,MFCD00941448 | |
| doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs | |
| hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride |
Especificaciones
| 25316-40-9 | |
| MFCD00077757,MFCD00077757,MFCD00941448 | |
| 4229251 | |
| doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs | |
| MWWSFMDVAYGXBV-FGBJBKNOSA-N | |
| hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride | |
| 129626538 | |
| Doxorubicin hydrochloride |
| C27H30ClNO11 | |
| 10mg | |
| 14,3439 | |
| Soluble in water. | |
| [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O | |
| 579.98 | |
| 579.99 |
Seguridad y manipulación
Nombre del producto
Palabra de advertencia
Clasificación
Indicaciones de peligro
Consejos de prudencia
Otros peligros
- Doxorubicin hydrochloride
Palabra de advertencia
- Danger
Clasificación
- Acute toxicity Category 4
- Serious eye damage/eye irritation Category 1
- Germ cell mutagenicity Category 1A
- Reproductive toxicity Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
Indicaciones de peligro
- H302-Harmful if swallowed.
- H315-Causes skin irritation.
- H318-Causes serious eye damage.
- H335-May cause respiratory irritation.
- H340-May cause genetic defects.
- H361fd-Suspected of damaging fertility. Suspected of damaging the unborn child.
Consejos de prudencia
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P310-Immediately call a POISON CENTER/doctor/.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
Otros peligros
- MIXTURE LIST-Contain: Doxorubicin hydrochloride
Título del producto
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