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ACROBiosystems Cynomolgus Nectin-4 Protein, His Tag
Brand: ACROBiosystems NE4-C52H4-1mg
Additional Details : Weight : 0.00010kg
Description
Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.0 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| XP_005541277.1 | |
| 1 mg | |
| Gly 32 - Ser 349 | |
| NECTIN4,LNIR, PRR4, PVRL4 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 36.0 kDa | |
| Cynomolgus Nectin-4, His Tag (NE4-C52H4) is expressed from human 293 cells (HEK293). It contains AA Gly 32 - Ser 349 (Accession # XP_005541277.1). | |
| -20°C | |
| Nectin-4 | |
| Cynomolgus Monkey | |
| PBS, pH7.4 | |
| HEK293 | |
| Immune Checkpoint Proteins |